A Comparison of the Sedative Effect of Dexmedetomidine and Midazolam on Patients Undergoing Gastrointestinal Endosonography Outside the Operating Room

Background: Patients may experience anxiety, discomfort, and pain during endoscopy, which cannot be tolerated without sedative drugs. Objectives: This study aimed to compare the effects of dexmedetomidine midazolam on patients undergoing endosonography outside operating room. Methods: randomized, double-blind clinical trial was conducted 126 aged 18 - 65 years old with American Society Anesthesiologists (ASA) physical status I II elective endosonography. were randomly divided into 2 groups. The group received (1 μg/kg) for 25 minutes propofol (0.5 mg/kg) fentanyl at start procedure. (0.03 μg/kg). Heart rate, mean arterial pressure (MAP), oxygen saturation (SpO2) recorded before 5, 10, 15 after starting Ramsay Sedation Scale (RSS) need an additional dose Numeric Pain Rating scale (Ambesh score) scores beginning, immediately after, 1 hour Nausea vomiting assessed using Visual Analogue in cooperation patient. Results: had significantly higher SpO2 RSS sedation than (P = 0.02). Overall, specialist satisfaction group. There no clinically significant difference score nausea frequencies between Conclusions: Dexmedetomidine is more effective gastrointestinal